Innate allorecognition
نویسندگان
چکیده
منابع مشابه
Evolutionary aspects of allorecognition
Dear Editor, Although frequently neglected, allorecognition phenomena exhibit suites of effector mechanisms, altogether featuring one of the main biological characteristics of living organisms. A recent workshop organized by the Münster Graduate School of Evolution at the University of Münster, Germany, focused on the evolutionary aspects of allorecognition and the potential links to immune sys...
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Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived 'passenger' dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct al...
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Ascidians (primitive chordates) are hermaphroditic animals, releasing sperm and eggs nearly simultaneously. But, many ascidians, including Ciona intestinalis and Halocynthia roretzi, show self-sterility or preference for cross-fertilization rather than self-fertilization. The molecular mechanisms underlying this allorecognition process are only poorly understood. We recently identified the gene...
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Human AATF genome, of about 108 kb size, maps on chromosome 17 at 17q11.2-q12. Interestingly, in the same chromosomal region are several other genes encoding proteins that either have binding affinity for nucleic acids or act as chemokines including CCL5. AATF was, originally, identified as the translational-product of a transcript which was down-regulated by TGF-β in human intestinal cells [1]...
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Nearly all colonial marine invertebrates are capable of allorecognition--the ability to distinguish between self and genetically distinct members of the same species. When two or more colonies grow into contact, they either reject each other and compete for the contested space or fuse and form a single, chimeric colony. The specificity of this response is conferred by genetic systems that restr...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2014
ISSN: 0105-2896
DOI: 10.1111/imr.12153